منابع مشابه
MOG antibody-associated diseases
In the past few years several studies have consistently reported the presence of high-titer serum IgG antibodies to conformational epitopes of the myelin oligodendrocyte glycoprotein (MOG) in predominantly pediatric patients with acquired demyelinating diseases. Moreover, MOG antibodies seem not only to distinguish patients with clinically isolated syndromes or multiple sclerosis (MS) from mono...
متن کاملMetabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease
The overlapping clinical features of relapsing remitting multiple sclerosis (RRMS), aquaporin-4 (AQP4)-antibody (Ab) neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-Ab disease mean that detection of disease specific serum antibodies is the gold standard in diagnostics. However, antibody levels are not prognostic and may become undetectable after tre...
متن کاملIntractable Hiccup in Demyelinating Disease with Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody
The patient was a 29-year-old man who presented with intractable hiccup at the onset of demyelinating disease. This was followed, in quick succession, by blurred vision, gait disturbance with myoclonic spasms and paresthesia in both legs, and the inability to urinate. Brain and spinal MRI revealed lesions in the parasagittal cingulate gyri, pulvinar, cerebral peduncles, superior colliculi, midd...
متن کاملThe role of glia in neurological disease
Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
متن کاملMOG antibody–positive, benign, unilateral, cerebral cortical encephalitis with epilepsy
OBJECTIVE To describe the features of adult patients with benign, unilateral cerebral cortical encephalitis positive for the myelin oligodendrocyte glycoprotein (MOG) antibody. METHODS In this retrospective, cross-sectional study, after we encountered an index case of MOG antibody-positive unilateral cortical encephalitis with epileptic seizure, we tested for MOG antibody using our in-house, ...
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ژورنال
عنوان ژورنال: Journal of Neurology
سال: 2018
ISSN: 0340-5354,1432-1459
DOI: 10.1007/s00415-018-9122-2